A new neuroprotective pinusolide derivative from the leaves of Biota orientalis.
نویسندگان
چکیده
A new pinusolide derivative, 15-methoxypinusolidic acid (1), and another new isopimarane diterpene, ent-isopimara-15-en-3 alpha,8 alpha-diol (2) with three known diterpenes, lambertianic acid (3), isopimara-8(9),15-dien-18-oic acid (4) and isopimara-7(8),15-dien-3 beta,18-diol (5) were isolated from the 90% MeOH fraction of Biota orientalis (L.) ENDL. (Cupressaceae) leaves. Chemical structures of 1-5 were elucidated by analyses of their spectral data, including the two-dimensional (2D) NMR technique. Compound 1 showed significant protective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
منابع مشابه
Evaluation of antioxidant activity of natural product compounds from Platycladus orientalis leaves
Background and objectives: Natural product compounds of plants have been used since ancient times and in folklore medicine for the treatment of many diseases and illnesses. Oxygen-centered free radicals and other reactive oxygen species, which are continuously, produced in vivo, result in cell death and tissue damage. Oxidative damage caused by free radicals may be rel...
متن کاملStudy of antioxidant enzymes activity of Fagus orientalis Lipesk to environmental changes along altitude gradient (Case Study: Gilan forests, Masal)
To understand the Eco physiological adaptation mechanisms of Fagus orientalis Lipesk to altitude changes, the activities of Peroxidase (POD), Catalase (CAT), and Ascorbate peroxidase (APX) in leaves of Fagus orientalis in different altitudes (A1: 700 m, A2: 1200 m, A3: 1700 m above sea level) Was studied in the forests of Guilan. The sampling of leaves was collected from southern and northern ...
متن کاملBioorganic investigation of encapsulated Cysteine derivative into polymeric nanocarrier
In this work, the copolymer-based synthesized Cysteine-loaded nanocarriers prepared by a routine protocol, coprecipitation method. It is the first report to investigate the neuroprotective potential and biocompatibility of Cysteine derivatives loaded into poly(ethylene glycol)-block-poly(ε−caprolactone) methyl ether (PEG-b-PCL). The average size of the polymeric/empty NCs was 89 nm and for poly...
متن کاملBioorganic investigation of encapsulated Cysteine derivative into polymeric nanocarrier
In this work, the copolymer-based synthesized Cysteine-loaded nanocarriers prepared by a routine protocol, coprecipitation method. It is the first report to investigate the neuroprotective potential and biocompatibility of Cysteine derivatives loaded into poly(ethylene glycol)-block-poly(ε−caprolactone) methyl ether (PEG-b-PCL). The average size of the polymeric/empty NCs was 89 nm and for poly...
متن کاملAssessment of heavy metals in Cypress (Thuja orientalis L.) in the Yazd Highway green belt
Dust storm is one of the criteria for air pollution, and pollution by Heavy Metal(HM) is one of the major environmental problems in the world. The objective of the present study was to assess some of HMs concentrations in the leaves and bark of cypress and atmospheric falling dust along the Yazd highway, Yazd Province, Iran. The total concentrations of cadmium (Cd), cobalt (Co), copper (Cu), ni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 50 6 شماره
صفحات -
تاریخ انتشار 2002